利用冷加壓試驗(yàn)研究偏頭痛患者的血管神經(jīng)偶聯(lián)機(jī)制
摘自：Cephalalgia 0(0) 1–10  International Headache Society 2014
作者：Andrej Fabjan, Fajko F Bajrovic,Bojan Musizza,Jernej Vidmar, Martin Strucl1 and Marjan Zalete

摘要：偏頭痛患者神經(jīng)血管耦合改變可能是腦干核團(tuán)調(diào)節(jié)功能受損的結(jié)果。利用冷加壓試驗(yàn)，可以刺激腦干核團(tuán)。本文測量了偏頭痛患者的冷加壓試驗(yàn)前后視覺誘發(fā)的腦血流速度變異（visually evoked cerebral blood flow velocity response，VEFR）

Introduction
In recent years, migraine has been viewed as a neurovascular disorder (1). Neuroradiological studies have shown that patients with migraine have an increased incidence of ischemic-like lesions, especially in the territory of posterior circulation (2). Clinical studies have suggested that migraine is an independent risk factor for ischemic stroke (3). The etiology of ischemic-like lesions in migraine is debated; nevertheless, the impairment of cerebrovascular regulation seems to be an important issue in migraine pathophysiology (4).
Single-photon emission tomography and magnetic resonance imaging studies have shown interictal perfusion changes in patients with migraine (5,6).Additionally, increased interictal cerebrovascular reactivity in patients with migraine has been shown
by functional transcranial Doppler, a method with good temporal resolution (7). It has been proposed that altered cerebrovascular reactivity to metabolic demand of active brain tissue in migraineurs is a consequence of impaired function of modulatory brainstem nuclei,which are an important source of perivascular……。
Participants and methods
……CBFV was measured using two 2MHz Delica EMS-9U transcranial Doppler ultrasound (TCD) probes (Shenzen Delicate Electronics, Shenzen, China……。

Study of neurovascular coupling during cold pressor test in patients with migraine.pdf